Gauged Kaluza-Klein AdS Pseudo-supergravity

We obtain the pseudo-supergravity extension of the D-dimensional Kaluza-Klein theory, which is the circle reduction of pure gravity in D+1 dimensions. The fermionic partners are pseudo-gravitino and pseudo-dilatino. The full Lagrangian is invariant under the pseudo-supersymmetric transformation, up to quadratic order in fermion fields. We find that the theory possesses a U(1) global symmetry that can be gauged so that all the fermions are charged under the Kaluza-Klein vector. The gauging process generates a scalar potential that has a maximum, leading to the AdS vacuum. Whist the highest dimension for gauged AdS supergravity is seven, our gauged AdS pseudo-supergravities can exist in arbitrary dimensions.Comment: Latex, 13 pages, typos corrected, version in PL

Immune Checkpoint in Glioblastoma: Promising and Challenging

Glioblastoma (GBM) is a severe malignant brain cancer with poor overall survival. Conventional intervention remains dismal to prevent recurrence and deterioration of GBM cell. Recent years have witnessed exciting breakthroughs in novel immune strategies, especially checkpoint inhibitors, some of which have become adjuvant setting after standard of care in melanoma. Several clinical trials of checkpoint inhibitors are ongoing in glioblastoma and other brain carcinomas. Plus, synergistic combinations of checkpoint inhibitors with conventional therapy strategies—radiotherapy, temozolomide, bevacizumab, and corticosteroids are now being exploited and applied in clinical settings. This review highlights the recent developments of checkpoints in GBM immunotherapy to provide a brief and comprehensive review of current treatment options. Furthermore, we will discuss challenges remained, such as unique immune system of central nervous system (CNS), immune-related toxicities, synergies, and adverse interactions of combination therapies

Tunable nonlinear optical bistability based on Dirac semimetal in photonic crystal Fabry-Perot cavity

In this paper, we study the nonlinear optical bistability (OB) in a symmetrical multilayer structure. This structure is constructed by embedding a nonlinear three-dimensional Dirac semimetal (3D DSM) into a solution filled one-dimensional photonic crystal Fabry-Perot cavity. OB stems from the third order nonlinear conductivity of 3D DSM and the local field of resonance mode could enhance the nonlinearity and reduce the thresholds of OB. This structure achieves the tunability of OB due to that the transmittance could be modulated by the Fermi energy. OB threshold and threshold width could be remarkably reduced by increasing the Fermi energy. Besides, it is found that the OB curve depends heavily on the angle of incidence of the incoming light, the structural parameters of the Fabry-Perot cavity, and the position of 3D DSM inside the cavity. After parameter optimization, we obtained OB with a threshold of 106 V/m. We believe this simple structure provides a reference idea for realizing low threshold and tunable all optical switching devices. Keywords: Optical bistability, Dirac semimetal, Fabry-Perot cavity

Broader HIV-1 neutralizing antibody responses induced by envelope glycoprotein mutants based on the EIAV attenuated vaccine

<p>Abstract</p> <p>Background</p> <p>In order to induce a potent and cross-reactive neutralizing antibody (nAb), an effective envelope immunogen is crucial for many viral vaccines, including the vaccine for the human immunodeficiency virus (HIV). The Chinese equine infectious anemia virus (EIAV) attenuated vaccine has controlled the epidemic of this virus after its vaccination in over 70 million equine animals during the last 3 decades in China. Data from our past studies demonstrate that the Env protein of this vaccine plays a pivotal role in protecting horses from both homologous and heterogeneous EIAV challenges. Therefore, the amino acid sequence information from the Chinese EIAV attenuated vaccine, in comparison with the parental wild-type EIAV strains, was applied to modify the corresponding region of the envelope glycoprotein of HIV-1 CN54. The direction of the mutations was made towards the amino acids conserved in the two EIAV vaccine strains, distinguishing them from the two wild-type strains. The purpose of the modification was to enhance the immunogenicity of the HIV Env.</p> <p>Results</p> <p>The induced nAb by the modified HIV Env neutralized HIV-1 B and B'/C viruses at the highest titer of 1:270. Further studies showed that a single amino acid change in the C1 region accounts for the substantial enhancement in induction of anti-HIV-1 neutralizing antibodies.</p> <p>Conclusions</p> <p>This study shows that an HIV envelope modified by the information of another lentivirus vaccine induces effective broadly neutralizing antibodies. A single amino acid mutation was found to increase the immunogenicity of the HIV Env.</p